- ￥577 - 19300
- TargetMol
- 美国
- T37548
- 2025年07月13日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
azido-FTY720
- 库存：
10
- 供应商：
TargetMol
- CAS号：
881914-35-8
- 规格：
500 μg/100 μg/5 mg/1 mg
| 规格： | 500 μg | 产品价格： | ￥2500.0 |
|---|---|---|---|
| 规格： | 100 μg | 产品价格： | ￥577.0 |
| 规格： | 5 mg | 产品价格： | ￥19300.0 |
| 规格： | 1 mg | 产品价格： | ￥4440.0 |
Product Introduction
Bioactivity
英文名:azido-FTY720
描述:FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.
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