- ￥2131 - 17098
- TargetMol
- 美国
- T37187
- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
D-erythro/L-threo Lysosphingomyelin (d18:1)
- 库存：
10
- 供应商：
TargetMol
- CAS号：
82970-80-7
- 规格：
50 mg/5 mg/10 mg
| 规格： | 50 mg | 产品价格： | ￥17098.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2131.0 |
| 规格： | 10 mg | 产品价格： | ￥3573.0 |
Product Introduction
Bioactivity
英文名:D-erythro/L-threo Lysosphingomyelin (d18:1)
描述:Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin.
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