- ￥560 - 3220
- TargetMol
- 美国
- T36359
- 2025年07月11日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
Dios-Arg (trifluoroacetate salt)
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1807353-31-6
- 规格：
5 mg/1 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥1900.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥560.0 |
| 规格： | 10 mg | 产品价格： | ￥3220.0 |
Product Introduction
Bioactivity
英文名:Dios-Arg (trifluoroacetate salt)
描述:Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It has been used, coupled to 1,2-dioleoyl-sn-glycero-3-PE , to bind siRNA and plasmid DNA to form cationic lipid nanoparticles for intracellular transport. Dios-Arg is cytotoxic to H1299 and HeLa cells (IC50s = 83.5 and 74.1 μg/ml, respectively).
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