- ￥2460 - 18300
- TargetMol
- 美国
- T36321
- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
C6 Urea Ceramide
- 库存：
10
- 供应商：
TargetMol
- CAS号：
486991-52-0
- 规格：
1 mg/10 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥2460.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥18300.0 |
| 规格： | 5 mg | 产品价格： | ￥9870.0 |
Product Introduction
Bioactivity
英文名:C6 Urea Ceramide
描述:C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116, but not RIE-1, cells. It reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model when administered at doses of 1.25, 2.5, and 5 mg/kg for five days.
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