- ￥770 - 3200
- TargetMol
- 美国
- T36176
- 2025年07月09日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
AMK (hydrochloride)
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1215711-91-3
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥3200.0 |
Product Introduction
Bioactivity
英文名:AMK (hydrochloride)
描述:AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7 macrophages when used at a concentration of 500 μM.2,3AMK (20 mg/kg) decreases MPTP-induced increases in lipid peroxidation in the cytosol and mitochondria from substantia nigra and striatum in a mouse model of MPTP-induced Parkinson’s disease.4
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