- ￥15000 - 25500
- TargetMol
- 美国
- T35942
- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
AZ 5704
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1941214-06-7
- 规格：
100 mg/25 mg/50 mg
| 规格： | 100 mg | 产品价格： | ￥25500.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥15000.0 |
| 规格： | 50 mg | 产品价格： | ￥19800.0 |
Product Introduction
Bioactivity
英文名:AZ 5704
描述:Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan in tumor bearing, immunocompromised mice. Orally bioavailable.
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文献和实验,Gregory B,Hover A,Chen MY,Luci J,Joo SJ,Handwerker D,Liang J,Boyd R,Hunicke- Smith S,Simpson ZB,Caven T, Sochat V,Shine JM,Gordon E,Snyder AZ,Adeyemo B,Petersen SE,Glahn D, McKay DR,Curran JE,Göring HHH,Carless MA,Blangero J,Frick L,Marcotte E, Mumford JA
Protocols for Studying Antizyme Expression and Function
Antizyme (AZ) is a key molecule in feedback regulation of cellular polyamines. It is induced by polyamines through stimulation of ribosomal frameshifting during its translation. In mammals, AZ is diverged into three paralogs, AZ1–3. Tissue
Identification, Assay, and Functional Analysis of the Antizyme Inhibitor Family
essential cellular functions, their intracellular concentration is tightly regulated via a unique autoregulatory circuit that responds to the intracellular concentration of polyamines. In the heart of this circuit is a small protein called antizyme (Az
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