- ￥997 - 13300
- TargetMol
- 美国
- T35646
- 2025年07月08日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
4-oxo-2-Nonenal
- 库存：
10
- 供应商：
TargetMol
- CAS号：
103560-62-9
- 规格：
1 mg/500 μg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥1870.0 |
|---|---|---|---|
| 规格： | 500 μg | 产品价格： | ￥997.0 |
| 规格： | 5 mg | 产品价格： | ￥7640.0 |
| 规格： | 10 mg | 产品价格： | ￥13300.0 |
Product Introduction
Bioactivity
英文名:4-oxo-2-Nonenal
描述:4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on proteins and causes protein cross-linking. [7][8] 4-oxo-2-Nonenal also modifies 2’-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.[4]
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文献和实验4-Hydroxy-2-Nonenal (4-HNE) Staining by Anti-HNE Antibody
In almost all aerobic cells, the oxygen metabolism generates reactive oxygen species (ROS), such as superoxide, hydroxyl radicals, and hydrogen peroxide. These ROS can peroxidize membrane lipids of a cell and its organelles
roles of DNA oxidation in various disease states and population or inter-individual differences in antioxidant defence and DNA repair. The analysis of urine, or indeed any extracellular matrix, for 8-oxo-7,8-dihydro-2ʹ-deoxyguanosine (8-oxodG), using
) and 4-hydroxy-2-nonenal (HNE) (3 ), a major product of lipid peroxidation and the most reactive of these compounds under physiological conditions (4 ). This fluorescent compound, characterized as a2-hydroxy-3-imino-1,2-dihydropyrrol derivative (3, R1 = R2
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