- ￥2110 - 14700
- TargetMol
- 美国
- T35622
- 2025年07月04日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
FKGK 18
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1071001-09-6
- 规格：
5 mg/25 mg/50 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥2110.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥8970.0 |
| 规格： | 50 mg | 产品价格： | ￥14700.0 |
| 规格： | 10 mg | 产品价格： | ￥3940.0 |
Product Introduction
Bioactivity
英文名:FKGK 18
描述:FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8% inhibition, respectively. FKGK 18 inhibits iPLA2β activity in cytosolic extracts from INS-1 cells overexpressing iPLA2β (IC50 = ~50 nM) as well as iPLA2γ activity in mouse heart membrane fractions (IC50s = ~1-3 μM). It inhibits glucose-induced increases in prostaglandin E2 production and insulin secretion in human pancreatic islets when used at a concentration of 10 μM and inhibits thapsigargin-induced apoptosis in INS-1 cells overexpressing iPLA2β in a concentration-dependent manner. FKGK 18 (20 mg/kg, 3 times per week) reduces blood glucose levels in an intraperitoneal glucose tolerance test, decreases the incidence of diabetes, and increases serum insulin levels in non-obese diabetic (NOD) mice.
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