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- 详细信息
- 技术资料
- 保存条件:
零下80~20°C
- 保质期:
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名:
α-MSH TFA
- 库存:
10
- 供应商:
TargetMol
- CAS号:
171869-93-5
- 规格:
5 mg/25 mg/1 mg/10 mg
| 规格: | 5 mg | 产品价格: | ¥3970.0 |
|---|---|---|---|
| 规格: | 25 mg | 产品价格: | ¥16500.0 |
| 规格: | 1 mg | 产品价格: | ¥857.0 |
| 规格: | 10 mg | 产品价格: | ¥7470.0 |
Product Introduction
Bioactivity
英文名:α-MSH TFA
描述:α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube formationin vitro.3It inhibits endotoxin-, ceramide-, TNF-α-, or okadaic acid-induced activation of NF-κB in U937 cells.1α-MSH reduces IL-6- or TNF-α-induced ear edema in mice.4It also prevents the development of adjuvant-induced arthritis in rats and increases survival in a mouse model of septic shock. Increased plasma levels of α-MSH are positively correlated with delayed disease progression and reduced death in patients with HIV.1

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