INF4E,88039-46-7

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INF4E

CAS No. : 88039-46-7

MCE 国际站：INF4E

产品活性：INF4E 是一种有效的 NLRP3 炎性小体体抑制剂。INF4E 抑制 caspase-1 和 NLRP3 ATP 酶的活性。INF4E 显示对 IR 诱导的心肌损伤和功能障碍的保护作用。

研究领域：Immunology/Inflammation

作用靶点：NOD-like Receptor (NLR)

In Vitro: INF4E (compound 9) preventes both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.

In Vivo: INF4E significantly reduces the in infarct size and lactate dehydrogenase release and improvement in postischemic left ventricular pressure.
INF4E attenuates the formation of NLRP3 inflammasome complex was induced by myocardial IR (ischemia/reperfusion) in a time-dependent way.

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