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82-95-1
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Buclizine
CAS No. : 82-95-1
MCE 国际站：Buclizine
产品活性：Buclizine 是具有口服活性的抗组胺、抗过敏化合物。Buclizine 是大鼠的强致畸剂，并具有抗肿瘤活性。
研究领域：GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation
作用靶点：Histamine Receptor
In Vitro: Buclizine (0.1-100 μM; 72 h) inhibits growth of MCF-7 cells.
Buclizine (9.625-77 μM; 72 h) arrests the cell cycle in the G1 phase in a dose-dependent manner.
Buclizine (0-75 μM; 72 h) decreases TCTP (translationally controlled tumor protein) and cell cycle regulatory proteins expression in MCF-7 cells, increases pro-apoptotic MCL-1S expression.
In Vivo: Buclizine dihydrochloride (30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation) shows potent teratogens in the rat.
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