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Please store the product under the recommended conditions in the Certificate of Analysis.
- 英文名：
(±)-Brompheniramine
- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- CAS号：
86-22-6
- 规格：
询盘
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Brompheniramine
CAS No. : 86-22-6
MCE 国际站：Brompheniramine
产品活性：Brompheniramine ((±)-Brompheniramine) 是一种有效的口服有效的烷基胺类抗组胺药。Brompheniramine 是一种选择性组胺 H1 受体 (histamine H1 receptor) 拮抗剂，Kd 为 6.06 nM。Brompheniramine 可阻断 hERG 通道 (hERG channels)、钙离子通道 (calcium channels) 和钠离子通道 (sodium channels)，IC50 分别为 0.90 μM、16.12 μM 和 21.26 μM。Brompheniramine 具有抗胆碱能、抗抑郁以及麻醉作用，可用于过敏性鼻炎和缓解疼痛的研究。
研究领域：GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Membrane Transporter/Ion Channel
作用靶点：Histamine Receptor | mAChR | Potassium Channel | Sodium Channel | Calcium Channel
In Vitro: Brompheniramine (0.1-100 μM) blocks hERG K+ channels expressed in CHO cells in a concentration-dependent manner with an IC50 of 0.90±0.14 μM, and reduced peak tail current amplitude measured at -60 mV (cells are depolarized for 2 s to +20 mV from a holding potential of -80 mV followed by a 3s repolarization back to -60 mV).
Brompheniramine (1, 10 and 100 μM) significantly shortens the APD50 and depresses the plateau phase on the action potential in guinea pig papillary muscle, as well as slightly prolongs the APD90 in guinea pig papillary muscle at 10 and 100 μM.
Brompheniramine (0.1-100 μM) inhibit the amplitude of the Ca2+ channel currents in rat ventricular myocytes by 14.1±1.1, 31.1±5.8, 38.0±3.8 and 90.2±3.7% at 0.1, 1, 10 and 100 μM, respectively.
Brompheniramine blocks muscarinic cholinergic receptors in human chinese hamster ovary (CHO) cells.
In Vivo: Brompheniramine (0.3-3 μM; SC, single dosage) induces cutaneous analgesia in rats.
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