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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1290628-31-7
- 规格：
5 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥2500.0 |
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AZ 12216052
CAS No. : 1290628-31-7
MCE 国际站：AZ 12216052
产品活性：AZ 12216052 是一种 mGluR8 正变结构调节剂，帮助 mGluR8 调节视网膜神经节细胞的信号输入。AZ 12216052 具有抗焦虑作用。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：mGluR
In Vitro: mGluR8 may modulates the synaptic inputs to retinal ganglion cells.
AZ 12216052 (10 μM) enhances the peak excitatory currents of ON-, OFF- currents in ON-OFF-ganglion cells, with a dependent way on the intensity of the light stimuli.
AZ 12216052 shows impact of cell differentiation and (0.01-1 μM; 24-48 h) reduces Dox-induced human neuroblastoma SH-SY5Y cell damage partially.
AZ 12216052 stimulates proliferation and attenuates staurosporine (St)- and doxorubicin (Dox)-induced toxicity in UN-SH-SY5Y cells.
AZ12216052 (10 μM) enhances glutamate activity of human mGluR8b receptor expressed in GHEK cells.
In Vivo: AZ 12216052 (10 mg/kg; i.p.; 2 h prior to testing) reduces measures of anxiety, without affecting the velocity of the mice.
AZ12216052 (10 mg/kg; i.p.; single dose) exhibits remaining anxiolytic effects, might involve mGluR4 in mGluR8−/− mice, as the mGluR4 PAM (Positive Allosteric Modulator) VU 0155041 also reduces measures of anxiety in wild-type mice.
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文献和实验,Gregory B,Hover A,Chen MY,Luci J,Joo SJ,Handwerker D,Liang J,Boyd R,Hunicke- Smith S,Simpson ZB,Caven T, Sochat V,Shine JM,Gordon E,Snyder AZ,Adeyemo B,Petersen SE,Glahn D, McKay DR,Curran JE,Göring HHH,Carless MA,Blangero J,Frick L,Marcotte E, Mumford JA
Protocols for Studying Antizyme Expression and Function
Antizyme (AZ) is a key molecule in feedback regulation of cellular polyamines. It is induced by polyamines through stimulation of ribosomal frameshifting during its translation. In mammals, AZ is diverged into three paralogs, AZ1–3. Tissue
Identification, Assay, and Functional Analysis of the Antizyme Inhibitor Family
essential cellular functions, their intracellular concentration is tightly regulated via a unique autoregulatory circuit that responds to the intracellular concentration of polyamines. In the heart of this circuit is a small protein called antizyme (Az
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