BMS-986141,1478711-48-6

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BMS-986141

CAS No. : 1478711-48-6

MCE 国际站：BMS-986141

产品活性：BMS-98614 是一种口服活性的、选择性的凝血酶受体蛋白酶激活受体-4 (PAR-4) (protease-activated receptor-4 (PAR-4)) 拮抗剂，其 IC₅₀ 值为 0.4 nM。BMS-98614 具有优异的抗血栓功效。

研究领域：GPCR/G Protein

作用靶点：Protease Activated Receptor (PAR)

In Vitro: BMS-986141 (compound 49) (0-1 μM) inhibits platelet aggregation induced by PAR4 agonist peptide with an IC₅₀ value of 2.2 nM.

In Vivo: BMS-986141 (compound 49) shows a slight but significant prolongation of KBT (kidney bleeding time) and demonstrates excellent anti-thrombotic efficacy at 0.5 mg/kg in cynomolgus monkey.

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