DHODH-IN-22,2450341-75-8

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DHODH-IN-22

CAS No. : 2450341-75-8

MCE 国际站：DHODH-IN-22

产品活性：DHODH-IN-22 是一种有效且具有选择性和口服活性的二氢乳清酸脱氢酶 (DHODH) 抑制剂，IC₅₀ 为 0.3 nM。DHODH-IN-22可用于研究急性髓系白血病 (AML)。

研究领域：Metabolic Enzyme/Protease

作用靶点：Dihydroorotate Dehydrogenase

In Vitro: DHODH-IN-22 (compound 29) exhibits antiproliferative activity against MOLM-13 and THP-1 cells.

In Vivo: DHODH-IN-22 (1.9-7.5 mg/kg; PO; QD for 5 days) significantly inhibits MOLM-13 tumor growth in mice, and exhibits no significant impact on body weight.
DHODH-IN-22 (2 mg/kg for IV and 10 mg/kg for PO; single dosage) has favorable pharmacokinetic property.
Pharmacokinetic Parameters of DHODH-IN-22 (compound 29) in mouse and rat.

	Mouse IV 2 mg/kg and PO 10 mg/kg	Rat IV 2 mg/kg and PO 10 mg/kg
CL (mL/min/kg)	7.3	7.6
Vdss (L/kg)	2.4	2.2
t1/2 (ng/mL)	5	4
Cmax (ng/mL)	3810	2193
tmax (h)	1.0	4.0
AUC0-inf (ng/mL·h)	23046	23807
F (%)	110	106

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