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- 英文名：
P18
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货期：询盘
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MedChemExpress LLC
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询盘
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DPTIP-prodrug 18
CAS No. : 2881068-33-1
MCE 国际站：DPTIP-prodrug 18
产品活性：DPTIP-prodrug 18 (P18) 是一种口服有效的、可透过血脑屏障的 DPTIP (HY-131002) 前体活性分子。DPTIP-prodrug 18 是一种有效的中性鞘磷脂酶 nSMase2 抑制剂。DPTIP-prodrug 18 通过抑制 nSMase2 活性，显著抑制 IL-1β 诱导的膜泡 (EV) 释放。DPTIP-prodrug 18 可用于脑损伤研究。
研究领域：Metabolic Enzyme/Protease
作用靶点：Phospholipase
In Vitro: DPTIP-prodrug 18 is metabolically stable with >75% intact prodrug remaining after 1 h of incubation at 37 °C.
In Vivo: DPTIP-prodrug 18 exhibits an excellent PK profile.
DPTIP-prodrug 18 shows significant inhibition of nSMase2 activity and IL-1β-induced EV release in mice.
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文献和实验Extracellular -Glucuronidase for Gene-Directed Enzyme-Prodrug Therapy
Most enzymes used for antibody-directed enzyme-prodrug therapy (ADEPT) and gene-directed enzyme-prodrug therapy (GDEPT) are of bacterial, yeast, or viral origin. These xenogeneic proteins can induce an immune response
Antibody-Directed Enzyme-Prodrug Therapy
and antibody engineering is now addressing these problems by allowing the creation of antibodies with required characteristics for specific purposes. Antibody-directed enzyme-prodrug therapy (ADEPT) is a complex two-phase system in which an enzyme is targeted
The Nitroreductase/CB1954 Enzyme-Prodrug System
The prodrug CB1954 (5-[aziridin-1-yl]-2,4-dinitrobenzamide) is a weak monofunctional alkylating agent originally synthesized at the Chester Beatty Laboratories in the late 1960s (1 ). The antitumor activity of CB1954 was determined
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