Cadisegliatin,859525-02-3

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Cadisegliatin

CAS No. : 859525-02-3

MCE 国际站：Cadisegliatin

产品活性：Cadisegliatin (TTP-399) 是一种潜在的肝脏选择性葡萄糖激酶 (GK) 激活剂，具有口服活性。Cadisegliatin 具有降血糖活性，Cadisegliatin 可用于 2 型糖尿病的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Glucokinase

In Vitro: Cadisegliatin (TTP-399) increases glucose metabolism in rat hepatocytes, the EC₅₀ values of lactate and glycogen in 15 nM glucose are 2.39 μM and 2.64 μM, respectively.

In Vivo: TTP399 (200 mg/kg, per os, p.o.) has no effect on plasma glucose and insulin in fasted rats.
TTP399 (75 or 150 mg/kg, per day, for 4 weeks) improves glucose homeostasis in ob/ob mouse model.
TTP399 (50 mg/kg, per day, for 13 weeks) is effective in reducing plasma glucose during an oral glucose tolerance test (OGTT) in minipigs model.

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