Palmatine hydroxide

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Palmatine hydroxide

CAS No. : 131-04-4

MCE 国际站：Palmatine hydroxide

产品活性：Palmatine hydroxide 是一种具有口服活性的、不可逆的 IDO-1 抑制剂，对 HEK 293-hIDO-1 和 rhIDO-1 的 IC₅₀ 分别为 3 μM 和 157 μM。Palmatine hydroxide 也能非竞争性抑制西尼罗病毒 (WNV) NS2B-NS3 蛋白酶，IC₅₀ 为 96 μM。Palmatine hydroxide 具有抗癌、抗炎、神经保护、抗细菌、抗病毒活性。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection  |  Epigenetics  |  Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：Indoleamine 2,3-Dioxygenase (IDO)  |  Virus Protease  |  Aurora Kinase  |  Apoptosis  |  Bacterial  |  Parasite

In Vitro: Palmatine (0-100 μM; 42 h) suppresses WNV with an EC₅₀ value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC₅₀ values of 26.4 μM and 7.3 μM, respectively.
Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation.
Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces apoptosis in colon cancer cells via the mitochondrial associated pathway.

In Vivo: Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells.
Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice.
Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice.
Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Apoptosis Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  Autophagy Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Anti-Aging Compound Library  |  Antibacterial Compound Library  |  Orally Active Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Neuroprotective Compound Library  |  Alkaloids Library  |  Anti-Blood Cancer Compound Library  |  Antiparasitic Compound library  |  Anti-Cancer Natural Product Library  |  Antiviral Traditional Chinese Medicine Active Compound Library  |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Cell Death Library  |  Serine/Threonine Kinase Inhibitor Library  |  MG-132  |  Rapamycin  |  Chloroquine  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  LY294002  |  Tamoxifen  |  Paclitaxel  |  Y-27632  |  Dexamethasone  |  Acetylcysteine  |  Puromycin dihydrochloride  |  Angiotensin II human  |  Dimethyl sulfoxide  |  2-Deoxy-D-glucose  |  Staurosporine  |  SB-431542  |  Actinomycin D  |  Deferoxamine mesylate  |  Bortezomib  |  5-Fluorouracil  |  Trametinib  |  Sorafenib  |  Oxaliplatin  |  Necrostatin-1  |  Gemcitabine  |  G-418 disulfate  |  Temozolomide  |  Rotenone  |  Mdivi-1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds