KGP94,1131456-28-4

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KGP94

CAS No. : 1131456-28-4

MCE 国际站：KGP94

产品活性：KGP94 是一种特异的 cathepsin L 抑制剂，IC₅₀为 189 nM。KGP94 抑制转移癌的运动性和侵袭性，对人类细胞的毒性低 (GI₅₀=26.9µM)。

研究领域：Metabolic Enzyme/Protease

作用靶点：Cathepsin

In Vitro: KGP94 (10 or 20 μM, 24 h) reduces expression of M2 (macrophage) markers (Arginase-1 and CD206) and cells invasion of primary bone marrow-derived macrophages or Raw264.7.
KGP94 (25 μM, 24 h) impairs the incasive capacities of both prostate and breat cancer cells by 53% and 88%, respectively.
KGP94 (25 μM, 24 h) suppresses secreted CTSL activity by 94% and 92% in PC-3ML and MDA-MB-231, repsectively.

In Vivo: KGP94 (i.p.; 20 mg/kg; once daily for 3 days) exhibits anti-metastatic and anti-bone resorptive efficacy in a prostate cancer bone metastasis model.

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