Anti-inflammatory agent 31,305

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Anti-inflammatory agent 31

CAS No. :

MCE 国际站：Anti-inflammatory agent 31

产品活性：Anti-inflammatory agent 31 是一种穿心莲内酯衍生物，是一种抗炎剂 (anti-inflammatory agent)。Anti-inflammatory agent 31 通过上游阻断 PI3K/Akt 和 ERK1/2 MAPK 激活来抑制 NF-kB 激活。Anti-inflammatory agent 31 能够恢复细胞内 GSH 水平并对肝脏具有保护作用。

研究领域：MAPK/ERK Pathway  |  Stem Cell/Wnt  |  NF-κB

作用靶点：ERK  |  NF-κB

In Vitro: Anti-inflammatory agent 31 (enone 17) (100, 200, and 400 μM; 24 h) prevents the DNA binding of the activated NF-κB p50 subunit in a dose-dependent manner.
Anti-inflammatory agent 31 reacts as a quick rate (K_GSH=0.076 M^-1.h^-1) and long half-live (T_1/2=6.47 h).
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) shows recovery effective of the intracellular GSH levels, and (5 μM) induced more than 2.5-fold increase in GSH levels as compared to the basal levels.
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) displays low cytotoxicity in LO2 and HEK293 cells with CC₅₀ of 14.68, 26.25 μM, respectively.

In Vivo: Anti-inflammatory agent 31 (enone 17) (i.p.; 0.3, 1.0 mg/kg) decreases total white blood cell and neutrophils counts, and alleviates LPS-induced acute lung injury in a dose-dependent manner in mouse.

相关产品：Phorbol 12-myristate 13-acetate  |  Bortezomib  |  PD98059  |  BAY 11-7082  |  Yoda 1  |  TAK-243  |  SCH772984  |  TBHQ  |  JSH-23  |  Sulfasalazine  |  Shikonin  |  Tauroursodeoxycholate  |  Pyrrolidinedithiocarbamate ammonium  |  Triptolide  |  Aspirin  |  Dihydroartemisinin  |  Baicalin  |  Ulixertinib  |  Honokiol  |  Parthenolide  |  Astragaloside IV  |  BAY 11-7085  |  5-Aminosalicylic Acid  |  CBL0137 hydrochloride  |  Rocaglamide  |  Piperlongumine  |  Betulinic acid  |  Isoginkgetin  |  Ravoxertinib

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds