AChE/HDAC-IN-1,2414053-06-6

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AChE/HDAC-IN-1

CAS No. : 2414053-06-6

MCE 国际站：AChE/HDAC-IN-1

产品活性：COX-2-IN-23 (compound A10) 是一种有效的 AChE 和 HDAC 抑制剂，其 IC₅₀ 值分别为 0.12 和 0.23 nM。COX-2-IN-23 具有抗氧化活性和金属螯合特性。COX-2-IN-23 可用于阿尔兹海默病研究。

研究领域：Neuronal Signaling  |  Epigenetics  |  Cell Cycle/DNA Damage

作用靶点：Cholinesterase (ChE)  |  HDAC

In Vitro: COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC₅₀ values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively.
COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%).
COX-2-IN-23 (compound A10) exhibits Cu²⁺ chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity.

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