In Vitro: Chromeceptin (94G6) (5 μM) inhibits IGF2 expression in Hep3B-derived TS cells in a time-dependent manner. ?Chromeceptin decreases the Phosphorylation levels of protein kinase B (AKT, Ser463) and rapamycin (mTOR, Ser 2481 and Ser 2448) in TS cells. ?Chromeceptin represses the phosphorylation at ser371 in mTOR effectors ribosomal protein S6 kinase (p70S6K).