In Vitro: COX-2/PI3K-IN-2 (compound 5f) (50-500 µg/mL, 72 hours) exerts potent antitumor activities against Breast cancer (MCF-7) cells. COX-2/PI3K-IN-2 (compound 5f) (10-150 µg/mL) has antioxidant properties with H2O2 scavenging activity equivalent to ascorbic acid and higher lysozyme inhibition (IC50=3.25 nM).