兔抗FBXO11多克隆抗体

中文名称： 兔抗FBXO11多克隆抗体

英文名称：Anti-FBXO11rabbitpolyclonalantibody

别名：F-boxprotein11;UBR6;VIT1;FBX11;PRMT9;IDDFBA;UG063H01

相关类别：一抗

储存：冷冻（-20℃）

宿主：Rabbit

抗原：FBXO11

反应种属：Human,Mouse,Rat

标记物：Unconjugate

克隆类型：rabbitpolyclonal

技术规格
 

Background:	ThisgeneencodesamemberoftheF-boxproteinfamilywhichisch aracterizedbyanapproximately40aminoacidmotif,theF-box.Th eF-boxproteinsconstituteoneofthefoursubunitsofubiquitinpro teinligasecomplexcalledSCFs(SKP1-cullin-F-box),whichfunctio ninphosphorylation-dependentubiquitination.TheF-boxprotei nsaredividedinto3classes:FbwscontainingWD-40domains,Fblsc ontainingleucine-richrepeats,andFbxscontainingeitherdifferent protein-proteininteractionmodulesornorecognizablemotifs.The proteinencodedbythisgenebelongstotheFbxsclass.Itcanfunctio nasanargininemethyltransferasethatsymmetricallydimethylates arginineresidues,anditactsasanadaptorproteintomediatethene ddylationofp53,whichleadstothesuppressionofp53function.This geneisknowntobedown-regulatedinmelanocytesfrompatients withvitiligo,askindisorder thatresultsindepigmentation.Polymorphismsinthisgeneareass ociatedwithchronicotitismediawitheffusionandrecurrentotitism edia(COME/ROM),ahearinglossdisorder,andtheknockoutoftheh omologousmousegeneresultsinthedeafmousemutantJeff(Jf),asi nglegenemodelofotitismedia.Alternativelysplicedtranscriptvarian tsencodingdistinctisoformshavebeenidentifiedforthisgene.[providedbyRefSeq,Jun2010]
Applications:	ELISA,IHC
Nameofantibody:	FBXO11
Immunogen:	FusionproteinofhumanFBXO11
Fullname:	F-boxprotein11
Synonyms:	UBR6;VIT1;FBX11;PRMT9;IDDFBA;UG063H01
SwissProt:	Q86XK2
ELISARecommendeddilution:	5000-10000
IHCpositivecontrol:	Humanlivercancer
IHCRecommenddilution:	100-300