兔抗ARNT多克隆抗体

中文名称： 兔抗ARNT多克隆抗体

英文名称：Anti-ARNTrabbitpolyclonalantibody

别名：ARNT;HIF-1beta;HIF1B;HIF1BETA;TANGO;bHLHe2

相关类别：一抗

储存：冷冻（-20℃）避光

宿主：Rabbit

抗原：ARNT

反应种属：Human,Mouse,Rat

标记物：Unconjugate

克隆类型：rabbitpolyclonal

技术规格
 

Background:	Hypoxia-induciblefactor1(HIF1)isaheterodimerictran scriptionfactorthatplaysacriticalroleinthecellularres ponsetohypoxia.TheHIF1complexconsistsoftwosub units,HIF-1αandHIF-1β,whicharebasichelix-loop-heli xproteinsofthePAS(Per,ARNT,Sim)family.HIF1reg ulatesthetranscriptionofabroadrangeofgenesthatfac ilitateresponsestothehypoxicenvironment,including genesregulatingangiogenesis,erythropoiesis,cellcycl e,metabolismandapoptosis.ThewidelyexpressedHIF- 1αistypicallydegradedrapidlyinnormoxiccellsbytheubi quitin/proteasomalpathway.Undernormoxiccondition s,HIF1αisprolinehydroxylatedleadingtoaconformation alchangethatpromotesbindingtothevonHippelLindaup rotein(VLH)E3ligasecomplex;ubiquitinationandproteas omaldegradationfollows.Bothhypoxicconditionsandch emicalhydroxylaseinhibitors(suchasdesferrioxaminean dcobalt)inhibitHIF-1αdegradationandleadtoitsstabiliza tion.Inaddition,HIF-1αcanbeinducedinanoxygen-indep endentmannerbyvariouscytokinesthroughthePI3K-AKT mTORpathway.HIF1βisalsoknownasAhRnucleartransloca tor(ARNT)duetoitsabilitytopartnerwiththearylhydrocar bonreceptor(AhR)toformaheterodimerictranscriptionfact orcomplex.TogetherwithAhR,HIF-1βplaysanimportantrolei nxenobioticsmetabolism.Inaddition,achromosomaltransloca tionleadingtoaTELARNTfusionproteinisassociatedwithacutem yeloblasticleukemia.StudiesalsofoundthatARNT/HIF1βexpres sionlevelsdecreasesignificantlyinpancreaticisletsfrompatients withtype2diabetes,suggestingthatHIF-1βplaysanimportantroleinpancreaticβ-cellfunction.
Applications:	WB
Nameofantibody:	ARNT
Immunogen:	FusionproteinofhumanARNT
Fullname:	arylhydrocarbonreceptornucleartranslocator
Synonyms：	ARNT;HIF-1beta;HIF1B;HIF1BETA;TANGO;bHLHe2
SwissProt:	P27540
WBPredictedbandsize:	87kDa
WBPositivecontrol:	Hepg2,MCF7,NIH3T3,U20SandHelacells
WBRecommendeddilution:	500-2000