兔抗CAMSAP3多克隆抗体

中文名称： 兔抗CAMSAP3多克隆抗体

英文名称：Anti-CAMSAP3rabbitpolyclonalantibody

别名：calmodulinregulatedspectrinassociatedproteinfamilymember3;NEZHA;PPP1R80;KIAA1543

相关类别：一抗

储存：冷冻（-20℃）

抗原：CAMSAP3

宿主：Rabbit

反应种属：Human,Mouse

标记物：Unconjugate

克隆类型：rabbitpolyclonal

技术规格

Background:	Keymicrotubule-organizingproteinthatspecificall ybindstheminus-endofnon-centrosomalmicrotub ulesandregulatestheirdynamicsandorganization (PubMed:19041755,PubMed:23169647).Specifica llyrecognizesgrowingmicrotubuleminus-endsanda utonomouslydecoratesandstabilizesmicrotubulelat ticeformedbymicrotubuleminus-endpolymerization (PubMed:24486153).Actsonfreemicrotubuleminus-en dsthatarenotcappedbymicrotubule-nucleatingproteins orotherfactorsandprotectsmicrotubuleminus-endsfromd epolymerization(PubMed:24486153).Inaddition,italsored ucesthevelocityofmicrotubulepolymerization(PubMed:24486153). Requiredforthebiogenesisandthemaintenanceofzonulaadherensby anchoringtheminus-endofmicrotubulestozonulaadherensandbyr ecruitingthekinesinKIFC3tothosejunctionalsites(PubMed:19041755). Requiredfororientingtheapical-to-basalpolarityofmicrotubulesinepi thelialcells:actsbytetheringnon-centrosomalmicrotubulestotheapica lcortex,leadingtotheirlongitudinalorientation(PubMed:27802168,Pu bMed:26715742).Playsakeyroleinearlyembryos,whichlackcentrosom es:accumulatesatthemicrotubulebridgesthatconnectpairsofcellsand enablestheformationofanon-centrosomalmicrotubule-organizingcen terthatdirectsintracellulartransportintheearlyembryo(Bysimilarity). Couplesnon-centrosomalmicrotubuleswithactin:interactionwithMA CF1attheminusendsofnon-centrosomalmicrotubules,tethersthemic rotubulestoactinfilaments,regulatingfocaladhesionsizeandcellmigr ation(PubMed:27693509).Playsakeyroleinthegenerationofnon-centr osomalmicrotubulesbyaccumulatinginthepericentrosomalregionand cooperatingwithKATNA1toreleasenoncentrosomalmicrotubulesfrom thecentrosome(PubMed:28386021).Throughthemicrotubulecytoske leton,alsoregulatestheorganizationofcellularorganellesincludingtheG olgiandtheearlyendosomes(PubMed:28089391).Throughinteraction withAKAP9,involvedintranslocationofGolgivesiclesinepithelialcells, wheremicrotubulesaremainlynon-centrosomal(PubMed:28089391).
Applications:	ELISA,IHC
Nameofantibody:	CAMSAP3
Immunogen:	SyntheticpeptideofhumanCAMSAP3
Fullname:	calmodulinregulatedspectrinassociatedproteinfamilymember3
Synonyms:	NEZHA;PPP1R80;KIAA1543
SwissProt:	Q9P1Y5
ELISARecommendeddilution:	5000-10000
IHCpositivecontrol:	Humancervicalcancer
IHCRecommenddilution:	100-300