兔抗MAPKAPK2(Ab-272) 多克隆抗体

中文名称： 兔抗MAPKAPK2(Ab-272)多克隆抗体

英文名称：Anti-MAPKAPK2(Ab-272)rabbitpolyclonalantibody

别名：MK2;MK-2;MAPKAP-K2

相关类别：一抗

储存：冷冻（-20℃）避光

抗原：MAPKAPK2(Ab-272)

宿主：Rabbit

反应种属：Human

标记物：Unconjugate

克隆类型：rabbitpolyclonal

技术规格

Background:	Stress-activatedserine/threonine-proteinkinaseinvolvedincytok inesproduction,endocytosis,reorganizationofthecytoskeleton, cellmigration,cellcyclecontrol,chromatinremodeling,DNAdamage responseandtranscriptionalregulation.Followingstress,itisphosph orylatedandactivatedbyMAPkinasep38-alpha/MAPK14,leadingtop hosphorylationofsubstrates.Phosphorylatesserineinthepeptidesequ ence,Hyd-X-R-X(2)-S,whereHydisalargehydrophobicresidue.Phosph orylatesALOX5,CDC25B,CDC25C,ELAVL1,HNRNPA0,HSF1,HSP27/HSPB1, KRT18,KRT20,LIMK1,LSP1,PABPC1,PARN,PDE4A,RCSD1,RPS6KA3,TAB3 andTTP/ZFP36.MediatesphosphorylationofHSP27/HSPB1inresponsetos tress,leadingtodissociateHSP27/HSPB1fromlargesmallheat-shockpro tein(sHsps)oligomersandimpairtheirchaperoneactivitiesanda bilitytoprotectagainstoxidativestresseffectively.Involvedininflamma toryresponsebyregulatingtumornecrosisfactor(TNF)andIL6productio npost-transcriptionally:actsbyphosphorylatingAU-richelements(AREs) -bindingproteinsELAVL1,HNRNPA0,PABPC1andTTP/ZFP36,leadingtore gulatethestabilityandtranslationofTNFandIL6mRNAs.Phosphorylationof TTP/ZFP36,amajorpost-transcriptionalregulatorofTNF,promotesitsbindi ngto14-3-3proteinsandreducesitsAREmRNAaffinityleadingtoinhibitiono fdependentdegradationofARE-containingtranscript.AlsoinvolvedinlateG2 /McheckpointfollowingDNAdamagethroughaprocessofpost-transcriptionalmRNAstabilization:followingDNAdamage,relocalizesfro mnucleustocytoplasmandphosphorylatesHNRNPA0andPARN,leadingto stabilizeGADD45AmRNA.Involvedintolllikereceptorsignalingpathway (TLR)indendriticcells:requiredforacuteTLRinducedmacropinocytosisbyp hosphorylatingandactivatingRPS6KA3.
Applications:	WB,IHC
Nameofantibody:	MAPKAPK2(Ab-272)
Immunogen:	Synthesizednon-phosphopeptidederivedfromhumanMAPKAPK2aroundthephosphorylationsiteofserine272(A-I-S(p)-P-G).
Fullname:	mitogen-activatedproteinkinase-activatedproteinkinase2
Synonyms：	MK2;MK-2;MAPKAP-K2
SwissProt:	P49137
IHCpositivecontrol:	Humanbreastcarcinomatissue
IHCRecommenddilution:	50-100
WBPredictedbandsize:	46kDa
WBPositivecontrol:	COScellslysate
WBRecommendeddilution:	500-3000