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NCF4 Mouse Monoclonal Antibody

[Clone ID: LBI1A7]
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  • ¥3300
  • Leading Biology
  • 美国
  • 2025年07月15日
  • WB 1:2000
  • Mouse
  • Human, Mouse, Rat
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 靶点

      NCF4

    • 应用范围

      WB 1:2000

    • 宿主

      Mouse

    • 适应物种

      Human, Mouse, Rat

    • 保质期

      1-2年

    • 供应商

      安诺伦(北京)生物科技有限公司

    • 标记物

      Unconjugated

    • 克隆性

      Monoclonal Antibody

    • 保存条件

      Stable for 1 year at -20°C from date of shipment. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

    • 形态

      Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

    • 亚型

      IgG1

    • 免疫原

      Full length human recombinant protein of human NCF4 (NP_000622) produced in HEK293T cell.

    • 规格

      100 ug

    别名:NCF; P40PHOX; SH3PXD4

    产品概述:Carrier-free (BSA/glycerol-free) NCF4 mouse monoclonal antibody,clone LBI1A7

    总结:The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

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    图标文献和实验
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