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4°C, sealed storage, away from moisture
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货期：1-2天
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MedChemExpress LLC
- CAS号：
2863676-89-3
- 规格：
5 mg/10 mg/25 mg/50 mg
| 规格： | 5 mg | 产品价格： | ￥1600.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥2400.0 |
| 规格： | 25 mg | 产品价格： | ￥5000.0 |
| 规格： | 50 mg | 产品价格： | ￥8000.0 |
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MPP hydrochloride
CAS No. : 2863676-89-3
MCE 国际站：MPP hydrochloride
产品活性：MPP hydrochloride 是一种强效的选择性 ER (雌激素受体)调节剂。MPP hydrochloride 可诱导子宫内膜癌和 oLE 细胞凋亡。MPP hydrochloride 可逆转 β - 雌激素的积极作用。在体内，MPP hydrochloride 对小鼠子宫 ERalpha 具有激动剂和拮抗剂的混合作用。
研究领域：Vitamin D Related/Nuclear Receptor | Apoptosis
作用靶点：Estrogen Receptor/ERR | Apoptosis
In Vitro: MPP (1, 5, 10, 25, 50 and 100 µM; 24 h) decreases cell viability with an IC50 value of 20.01 µM in RL95-2 cells.
MPP dihydrochloride shows antiproliferative activity at a concentration of 10 μM in RL95-2 cells.
MPP dihydrochloride (20 µM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα.
In Vivo: MPP (Low dose 20 μg/kg body weight or high dose 200 μg/kg body weight) leads to a dose-dependent attenuation of percent prepulse inhibition (PPI).
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文献和实验Guanidine Hydrochloride Purification of Proteins From SDS
Pepstatin A (2.0 mg/ml)10 ml Leupeptin (1.0 mg/ml)10 ml Aprotinin (5.0 mg/ml)(Protease Inhibitor Cocktail Sigma #P8340)Denaturation Buffer6 M guanidine hydrochloride 57.3 g G-HCl20 mM Hepes 7.9 2 ml 1M Hepes pH 7.910 mM KCl 0.074 g KCl0.5 mM DTT 100 ml 0.5 M
Guanidine Hydrochloride Purification of Proteins From SDS PAGE
(Sigma #P7626) 10 ml Pepstatin A (2.0 mg/ml) 10 ml Leupeptin (1.0 mg/ml) 10 ml Aprotinin (5.0 mg/ml) (Protease Inhibitor Cocktail Sigma #P8340) Denaturation Buffer 6 M guanidine hydrochloride 57.3 g G-HCl 20 mM Hepes 7.9 2 ml 1M Hepes pH 7.9 10 mM
Packed column subcritical and/or supercritical fluid chromatography (p-sub or pSFC) has been used as a powerful chiral separation technique, whereby a mobile phase produces low viscosity, a high diffusion coefficient, and a solvating power. P
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