Mtb ATP synthase-IN-1

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Mtb ATP synthase-IN-1

CAS No. : 2642394-38-3

MCE 国际站：Mtb ATP synthase-IN-1

产品活性：Mtb ATP synthase-IN-1 (compound 6ab) 是一种有效的 结核分枝杆菌 (Mtb) ATP 合成抑制剂，对 Mtb 的 MIC 为 0.452 ~ 0.499 μg/mL。Mtb ATP synthase-IN-1 代谢稳定性好，细胞毒性低 (Vero IC₅₀ > 64 μg/mL)，具有一定的口服生物利用度。Mtb ATP synthase-IN-1 可用于抗结核分枝杆菌的研究。

研究领域：Anti-infection  |  Membrane Transporter/Ion Channel

作用靶点：Bacterial  |  ATP Synthase

In Vivo: Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability.
Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse.

	PO (50 mg/kg)	IV (5 mg/kg)
Cmax (ng/mL)	1333	1241
Tmax (h)	0.83
T1/2 (h)	0.51	0.33
AUC0-t (ng/mL·h)	2197	1667
AUC0-∞ (ng/mL·h)	2198	1672
MRT0-∞ (ng/mL)	1.36	0.28
CL (mL/min/kg)		51.4
F (%)	13.1

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