TC-SP 14,1257093-40-5

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TC-SP 14

CAS No. : 1257093-40-5

MCE 国际站：TC-SP 14

产品活性：TC-SP 14 (compound 14) 是一种口服有效的 S1P1 激动剂 (EC₅₀ = 0.042 μM)，在 S1P3 处活性极低 (EC₅₀ = 3.47 μM)。TC-SP 14 可显著降低血液淋巴细胞计数，减弱对抗原挑战的迟发型超敏反应(DTH)。

研究领域：GPCR/G Protein

作用靶点：LPL Receptor

In Vitro: TC-SP 14 (compound 14) neither inhibits nor induces human cytochrome P450 enzymes, is nonmutagenic, and dose not significantly inhibit the hERG channel.

In Vivo: TC-SP 14 (compound 14) (0-3 mg/kg, Orally, once) produces a dose-dependent reduction in circulating blood lymphocytes 24 h postdose.
TC-SP 14 (0-3 mg/kg, Orally, daily for 10 days) significant reduces ovalbumin (OVA)-induced ear swelling.
TC-SP 14 (2-15 mg/kg, IV or PO, once) possesses acceptable characteristics.
Pharmacokinetic Parameters of TC-SP 14 in female Sprague-Dawley rats and male Cynomolgus .

species	rat	NHP
CL (L/h/kg)	0.33	0.50
Vss (L/kg)	3.3	1.6
T1/2 (h)	7.5	35.2
MRT (h)	10	3.3
% F	68	23

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