Hexa-D-arginine is an inhibitor of the proprotein convertase furin (Ki = 100 nM).{62737} It also inhibits West Nile virus nonstructural protein 3 (NS3) protease (Ki = 478 nM). Hexa-D-arginine (1 µg/ml) reduces the proliferation, invasion, and migration
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A furin inhibitor (Ki = 100 nM); inhibits West Nile virus NS3 protease (Ki = 478 nM); reduces the proliferation, invasion, and migration of SW 1990 and PaTu 8988 pancreatic cancer cells, as well as decreases the levels of N-cadherin and vimentin and increases E-cadherin levels in the same cells at 1 µg/ml; improves survival in a rat model of anthrax toxemia induced by protective antigen and lethal factor