Ac2-26 is an annexin A1-mimetic peptide that corresponds to amino acids 2-26 of the N-terminus in annexin A1.{57827} It binds to HEK293 cells expressing human formyl peptide receptor 1 (FPR1) or FPR2, also known as FPR-like 1 (FPRL1; EC50s = 1.4 and 1.8
An annexin A1-mimetic peptide; binds to HEK293 cells expressing human FPR1 or FPR2 (EC50s = 1.4 and 1.8 µM, respectively, in a radioligand binding assay); inhibits PMN rolling over TNF-α-stimulated HUVECs at 10 and 30 µM; inhibits LPS-induced production of PGE2 and NO in rat microglial cells at 10 and 100 µg/ml; decreases pulmonary edema in a rat model of ventilator-induced ischemia-reperfusion injury at 0.5 and 1 mg/kg