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CS1
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Please store the product under the recommended conditions in the Certificate of Analysis.
货期:电询
MedChemExpress LLC
1448009-94-6
电询
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 1448009-94-6
MCE 国际站:CS1
产品活性:CS1 是一种有效的 DNA Topo II 抑制剂。CS1 具有广谱的体外抗肿瘤作用、体内低毒性和潜在的抗多药耐药能力。CS1 导致 DNA 损伤、细胞周期停滞在 G2/M 期和细胞凋亡apoptosis。
研究领域:Cell Cycle/DNA Damage | Apoptosis
作用靶点:Topoisomerase | Apoptosis
In Vitro: CS1 shows cytotoxicity with IC50 values of 16.92 and 18.88 µM for MCF-7 and MCF7/ADR cells, respectively. CS1 (10, 50, 100 µM) inhibits the activity of topoisomerase II α (Topo IIα).CS1 (0-20 µM) shows antiproliferation activity in cancer cells.CS1 (2.5, 5, 10 µM) induces cell cycle arrest at the G2/M phase.CS1 (2.5, 5, 10 µM) induces cell apoptosis.CS1 (5, 10, 15 µM; 24 h) induces DNA breaks in MDA-MB-231 cells.
In Vivo: CS1 (20 mg/kg; i.v.; every other day for two weeks) shows antitumor effects.
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