Topoisomerase I/II inhibitor 2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Topoisomerase I/II inhibitor 2

CAS No. : 2770804-58-3

MCE 国际站：Topoisomerase I/II inhibitor 2

产品活性：Topoisomerase I/II inhibitor 2 (compound 1a) 是一种有效的拓扑异构酶 (Topoisomerase) 抑制剂，Huh7 与 LM9 细胞中的 IC₅₀ 分别为 9.82 μM 和 6.83 μM。Topoisomerase I/II inhibitor 2 对 DNA 拓扑异构酶 I/II 具有双重抑制，也能抑制小鼠模型中的异种移植肿瘤。Topoisomerase I/II inhibitor 2 具有研究肝癌的潜在价值。

研究领域：Cell Cycle/DNA Damage

作用靶点：Topoisomerase

In Vitro: Topoisomerase I/II inhibitor 2 (compound 1a) (0-150 μM; 72 hours) has favourable anti-proliferative activity in cancer cell lines, and better inhibitory activity on two human hepatocellular carcinoma cell lines (HuH7, LM9).
Topoisomerase I/II inhibitor 2 (20 μM; 24 hours) has no damage to the DNA of HuH7 cells while some damage is noticed on LM9 cells.
Topoisomerase I/II inhibitor 2 (1.25-8 μM; 1-2 weeks) inhibits cell proliferation of LM9 and Huh7 in a concentration-dependent manner.
Topoisomerase I/II inhibitor 2 (1.25-8 μM; 24 hours) has a good inhibitory effect on the migration and invasion of LM9 and HuH7 cells with concentration-dependent manner.
Topoisomerase I/II inhibitor 2 (0-20 μM; 24 hours) can inhibit the expression of matrix metalloproteinases-9 (MMP-9) in LM9 and HuH7 cells.
Topoisomerase I/II inhibitor 2 (0-20 μM; 48 hours) inhibits cells proliferation by blocking cell cycle at the G₂/M phase.
Topoisomerase I/II inhibitor 2 (3.5-20 μM; 48 hours) can injure mitochondrial function and induce cell apoptosis in a concentration-dependent manner.

相关产品：Doxorubicin hydrochloride  |  Etoposide  |  Exatecan mesylate  |  SN-38  |  Irinotecan  |  Camptothecin  |  Topotecan hydrochloride  |  Daunorubicin hydrochloride  |  Mitoxantrone  |  Berberine chloride  |  Epirubicin hydrochloride  |  Ciprofloxacin  |  Levofloxacin  |  Betulinic acid  |  EIDD-1931  |  Suramin sodium salt  |  Idarubicin hydrochloride  |  Gepotidacin  |  β-Lapachone  |  Aldoxorubicin  |  Pirarubicin  |  Teniposide

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds