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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2863686-81-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2198.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1180.0 |
| 规格： | 5 mg | 产品价格： | ￥2610.0 |
| 规格： | 10 mg | 产品价格： | ￥4140.0 |
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DRB18
CAS No. : 2863686-81-9
MCE 国际站：DRB18
产品活性：DRB18 是一种有效的葡萄糖转运蛋白 (GLUT) 泛抑制剂。DRB18 通过改变葡萄糖相关途径中代谢产物的丰度来改变 A549 细胞中的能量相关代谢。DRB18 最终可导致细胞阻滞在 G1/S 期，增加氧化应激和坏死细胞死亡。DRB18 具有抗肿瘤活性。
研究领域：Membrane Transporter/Ion Channel
作用靶点：GLUT
In Vitro: DRB18 (0-10 μM; 30 min) reduces glucose uptake in GLUT1-4-expressed HEK293 cell lines in a dose-dependent manner with IC50s varying from ~ 900 nM to ~ 9 μM.
?DRB18 (5 and 10 μM; 72 hours) causes cell cycle arrest in the G1/S phase transition.
?DRB18 (5 and 10 μM; 72 hours) increases ROS levels in A549 cells.
?DRB18 (5 and 10 μM; 72 hours) reduces expression of glycosylated GLUT1 and GLUT2-4 in A549 cells in a dose-dependent manner.
In Vivo: DRB18 (10 mg/kg; IP; thrice a week for 5 weeks) inhibits tumors volume by 44% and tumors weight by 43%.
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