Biacetyl monoxime

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Biacetyl monoxime

CAS No. : 57-71-6

MCE 国际站：Biacetyl monoxime

产品活性：Biacetyl monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶 (myosin ATPase) 抑制剂，是一种骨骼肌和心肌收缩抑制剂。Biacetyl monoxime 也是一种特征良好的骨骼肌肌球蛋白 II（myosin-II）的化学和运动活性的非竞争性抑制剂。Biacetyl monoxime 诱导肌质网 Ca²⁺ 释放。

研究领域：Membrane Transporter/Ion Channel  |  Cytoskeleton

作用靶点：Na+/K+ ATPase  |  Myosin

In Vitro: Biacetyl monoxime (Diacetyl monoxime) (50 mM, 6 and 48 h) decreases cellulase secretion in C. cinerea.
Biacetyl monoxime (50 mM, 2 and 4 h) disrupts the localization of the Golgi apparatus, but not that of the endoplasmic reticulum.
Biacetyl monoxime (0-30 mM) induces SR Ca²⁺ release (no efflux inhibitors) in a concentration-dependent manner, with a maximal reduction of 72% of SR Ca²⁺ at pCa 6.0.
Biacetyl monoxime acts as a chemical phosphatase, which has led to speculation that dephosphorylation of key Ca²⁺ channel proteins may be involved in its inhibition of contraction.
Biacetyl monoxime does not inhibit the ATPase activity of two different myosin-I isoforms, myosin-V, or myosin-VI.
Biacetyl monoxime (0-50 mM) suppresses L-type Ca²⁺ current of single cardiac myocytes isolated from SHR and WKY rats.
Biacetyl monoxime significantly reduces the duration of both spontaneous and electrically stimulated action potentials of cultured neonatal rat cardiomyocytes.

In Vivo: Biacetyl monoxime (0-200 mg/kg; i.v.; once) shows hypotensive effect.
Biacetyl monoxime (0-205 mg/kg; i.p.; once) shows anticonvulsant effect against Picrotoxin (HY-101391)-induced convulsions.

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