PD-1/PD-L1-IN-24,2667680-33-1

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PD-1/PD-L1-IN-24

CAS No. : 2667680-33-1

MCE 国际站：PD-1/PD-L1-IN-24

产品活性：PD-1/PD-L1-IN-24 是一种高效的 PD-1/PD-L1 抑制剂，IC₅₀ 为 1.57 nM。PD-1/PD-L1-IN-24 通过提高 IFN-γ 来在细胞水平上恢复 T 细胞功能。PD-1/PD-L1-IN-24 对 PBMCs 具有较低的细胞毒性。

研究领域：Immunology/Inflammation

作用靶点：PD-1/PD-L1

In Vitro: PD-1/PD-L1-IN-24 (compound 39) (0-10 μM; 6 hours) significantly releases PD-L1-mediated inhibition of PD-1-expressing Jurkat T cells at the concentration of 10 μM.
PD-1/PD-L1-IN-24 (0.003-20 μM; 72 hours) exhibits no significant toxicity at concentrations ranging from 0.003 to 2.22 μM, and the IC₅₀ is 12.42 μM.
PD-1/PD-L1-IN-24 (0.082, 0.247, 0.741 and 2.222 μM; 72 hours) significantly elevates the secretion of IFN-γ with a dose-dependent manner in T cell-tumor co-culture cells.

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