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2763226-84-0
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Anti-inflammatory agent 17
CAS No. : 2763226-84-0
MCE 国际站：Anti-inflammatory agent 17
产品活性：Anti-inflammatory agent 17 是一种有效的具有口服活性的消炎药。Anti-inflammatory agent 17 在体外实验中抑制 IL-6 和 TNF-α 的释放且无细胞毒性。Anti-inflammatory agent 17 在体内显示出抗炎活性。Anti-inflammatory agent 17 具有研究急性肺损伤 (ALI) 的潜力。
研究领域：Immunology/Inflammation | Apoptosis
作用靶点：Interleukin Related | TNF Receptor
In Vitro: Anti-inflammatory agent 17 (compound 5b) (10 µM; 24 h) displays no toxicity in J774a.1 cells.
Anti-inflammatory agent 17 (1.25, 2.5, 5, 10 µM; 2 h) inhibits the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner.
In Vivo: Anti-inflammatory agent 17 (20 mg/kg; intragastric administration) exhibits protective effect on LPS (lipopolysaccharide)-induced ALI in mice.
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文献和实验Chemoprevention of Lung Cancer
and non steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for colon cancer“ (1 ). This somewhat pessimistic statement reflects the outcome of several clinical trials that examined whether human lung cancer could effectively be prevented
www.gehealthcare.com GE Healthcare Bio-Sciences AB Björkgatan 30 751 84 Uppsala Sweden 71-7096-00 AE 07/2006 Elanders Östervåla 2006 12345 Elanders Östervåla 2006 12345 Elanders Östervåla 2006
from Zingiberaceae turmeric, has strong anti-inflammatory, antioxidant and antitumor properties. However, the anticarcinogenic mechanism of curcumin has yet to be fully elucidated. Epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF
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