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RIP1/RIP3/MLKL
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4°C, stored under nitrogen
货期:1-2天
MedChemExpress LLC
2682850-41-3
1 mg/5 mg/10 mg
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 2682850-41-3
MCE 国际站:RIP1/RIP3/MLKL activator 1
产品活性:RIP1/RIP3/MLKL activator 1 (Compound 6i) 是一种有效的抗胶质瘤 (anti-glioma) 活性分子。RIP1/RIP3/MLKL activator 1 通过激活 RIP1/RIP3/MLKL 通路诱导细胞坏死 (necroptosis)。 RIP1/RIP3/MLKL activator 1 可透过血脑屏障。
研究领域:Apoptosis | MAPK/ERK Pathway
作用靶点:RIP kinase | Mixed Lineage Kinase | Necroptosis
In Vitro: RIP1/RIP3/MLKL activator 1 (Compound 6i) (96 h) shows antiproliferative activities in human glioma cell lines.RIP1/RIP3/MLKL activator 1 (0-4 µM, 0-72 h) exhibits remarkable antiproliferative activity for U251 cells in a time- and concentration-dependent manner.RIP1/RIP3/MLKL activator 1 (10 µM, 0-72 h) shows acceptable stability.RIP1/RIP3/MLKL activator 1 (0-2 µM, 24 h) effectively inhibits the migration of U251 cells.RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway, and induces mitochondrial depolarization in U251 cells.RIP1/RIP3/MLKL activator 1 could not induce apoptosis in U251 cells.
In Vivo: RIP1/RIP3/MLKL activator 1 (Compound 6i) (2.50 ng/tail; i.v.; 48 h) inhibits U251 cell proliferation in vivo and exerts acceptable BBB permeability.
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