KPNA2 (Kpna2) (NM_010655) Mus

产品概述：Purified recombinant protein of karyopherin (importin) alpha 2, Asn70-End, tag free, expressed in E.coli, 50ug 蛋白长度：NQGTVNWSVE DIVKGINSNN LESQLQATQA ARKLLSREKQ PPIDNIIRAG LIPKFVSFLG KTDCSPIQFE SAWALTNIAS GTSEQTKAVV DGGAIPAFIS LLASPHAHIS EQAVWALGNI AGDGSAFRDL VIKHGAIDPL LALLAVPDLS TLACGYLRNL TWTLSNLCRN KNPAPPLDAV EQILPTLVRL LHHNDPEVLA DSCWAISYLT DGPNERIEMV VKKGVVPQLV KLLGATELPI VTPALRAIGN IVTGTDEQTQ KVIDAGALAV FPSLLTNPKT NIQKEATWTM SNITAGRQDQ IQQVVNHGLV PFLVGVLSKA DFKTQKEAAW AITNYTSGGT VEQIVYLVHC GIIEPLMNLL SAKDTKIIQV ILDAISNIFQ AAEKLGETEK LSIMIEECGG LDKIEALQRH ENESVYKASL NLIEKYFSVE EEEDQNVVPE TTSEGFAFQV QDGAPGTFNF 表达系统：E. coli 种属：Mus musculus 标签类型：Tag free 分子量：49.8kDa 通用名：Kpna2 总结：Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.[UniProtKB/Swiss-Prot Function] 形式：Liquid 浓度：>50 ug/mL as determined by microplate BCA method 纯度：> 90% as determined by SDS-PAGE and Coomassie blue staining 储存溶液：50mM Tris, pH8.0, 500mM NaCl, 10% glycerol 别名：2410044B12Rik; IPOA1; PTAC58; Rch1