Prothrombin (F2) (NM_000506) H

产品概述：Recombinant protein of human coagulation factor II (thrombin) (F2) 蛋白长度：Recombinant protein was produced with GoldORF clone, [GH38452V]. Click on the GoldORF clone link to view cDNA and protein sequences. 表达系统：HEK293T 种属：Human 标签类型：C-Myc/DDK 分子量：67.5 kDa 通用名：F2 总结：This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020] 形式：Liquid 浓度：>50 ug/mL as determined by microplate BCA method 纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液：25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol 别名：PT; RPRGL2; THPH1