产品概述:Recombinant protein of human troponin I type 3 (cardiac) (TNNI3)蛋白长度:Recombinant protein was produced with GoldORF clone, [GH44360V]. Click on the GoldORF clone link to view cDNA and protein sequences.表达系统:HEK293T种属:Human标签类型:C-Myc/DDK分子量:23.8 kDa通用名:TNNI3总结:Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]形式:Liquid浓度:>50 ug/mL as determined by microplate BCA method纯度:> 80% as determined by SDS-PAGE and Coomassie blue staining储存溶液:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol别名:CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1