Akr1b3 (NM_009658) Mouse Recom

产品概述：Purified recombinant protein of Mouse aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug 蛋白长度：A DNA sequence from Mouse cDNA ORF Clone, [GM34159V], encoding Mouse full-length Akr1b3. 表达系统：HEK293T 种属：Mouse 标签类型：C-MYC/DDK 分子量：35.7 kDa 通用名：Akr1b3 总结：Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:17381426, PubMed:19010934, PubMed:7851421). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins (PubMed:19010934). Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (By similarity).[UniProtKB/Swiss-Prot Function] 形式：Liquid 浓度：>50 ug/mL as determined by microplate BCA method 纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液：25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. 别名：Ahr-1; Ahr1; Akr1b1; Aldor1; Aldr1; ALR2; AR