产品概述:Purified recombinant protein of Mouse misshapen-like kinase 1 (zebrafish) (cDNA clone MGC:63403 IMAGE:6833893), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug蛋白长度:A DNA sequence from Mouse cDNA ORF Clone, [GM41063V], encoding Mouse full-length Mink1.表达系统:HEK293T种属:Mouse标签类型:C-MYC/DDK分子量:150.2 kDa通用名:Mink1总结:Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.[UniProtKB/Swiss-Prot Function]形式:Liquid浓度:>50 ug/mL as determined by microplate BCA method纯度:> 80% as determined by SDS-PAGE and Coomassie blue staining储存溶液:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.别名:B55, MINK, RP23-122P1.6