GSTM1 (NM_146421) Human Recomb

产品概述：Purified recombinant protein of Human glutathione S-transferase mu 1 (GSTM1), transcript variant 2, full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug 蛋白长度：A DNA sequence encoding human full-length GSTM1 表达系统：E. coli 种属：Human 标签类型：N-GST and C-His 分子量：49.1 kDa 通用名：GSTM1 总结：Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] 形式：Liquid 浓度：>50 ug/mL as determined by microplate BCA method 纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining 储存溶液：25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl. 别名：GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4; GTM1; H-B; MU; MU-1