A synthesized peptide derived from human ErbB4/HER4
规格:
50 µl/100 µl/200 µl
规格:
50 µl
产品价格:
¥1650.0
规格:
100 µl
产品价格:
¥2685.0
规格:
200 µl
产品价格:
¥4230.0
分子量:Calculated MW: 160kDa
Observed MW: 180kDa
细胞定位:Cell membrane, Mitochondrion, Nucleus, Single-pass type I membrane protein
稀释方法:WB 1:500 - 1:2000
总结:This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]