![[KO Validated] HIF1AN/FIH1 Rabbit mAb (AMR12812N)](https://img1.dxycdn.com/2022/0526/799/0702543970363690553-14.jpg)
- ￥1965 - 5040
- Leading Biology
- AMR12812N
- 美国
- 2025年07月08日
- Rabbit
- Human
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- 详细信息
- 技术资料
- 靶点：
FIH1
- 浓度：
Affinity purification
- 宿主：
Rabbit
- 适应物种：
Human
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 保存条件：
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 形态：
形式：Liquid 储存溶液：Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
- 亚型：
IgG
- 免疫原：
A synthesized peptide derived from human HIF1AN/FIH1
- 规格：
50 µl/100 µl/200 µl
| 规格： | 50 µl | 产品价格： | ￥1965.0 |
|---|---|---|---|
| 规格： | 100 µl | 产品价格： | ￥3075.0 |
| 规格： | 200 µl | 产品价格： | ￥5040.0 |
分子量：Calculated MW: 40kDa
Observed MW: 40kDa
细胞定位：Cytoplasm, Nucleus, perinuclear region
稀释方法：WB 1:500 - 1:2000
总结：Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD. Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Observed MW: 40kDa
细胞定位：Cytoplasm, Nucleus, perinuclear region
稀释方法：WB 1:500 - 1:2000
总结：Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD. Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
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[KO Validated] HIF1AN/FIH1 Rabbit mAb (AMR12812N)
￥1965 - 5040
