A synthesized peptide derived from human PEN2/PSENEN
规格:
50 µl/100 µl/200 µl
规格:
50 µl
产品价格:
¥1650.0
规格:
100 µl
产品价格:
¥2685.0
规格:
200 µl
产品价格:
¥4230.0
分子量:Calculated MW: 13kDa
Observed MW: 14kDa
稀释方法:WB 1:500 - 1:2000
IF 1:50 - 1:200
总结:Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]