- ￥1425 - 3930
- Leading Biology
- APR22062N
- 美国
- 2025年07月15日
- WB (Homo sapiens)
- Rabbit
- Human, Mouse
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- 详细信息
- 技术资料
- 靶点：
RBM25; NET52; RED120; RNPC7; S164; Snu71; fSAP94
- 浓度：
Affinity purification
- 应用范围：
WB (Homo sapiens)
- 宿主：
Rabbit
- 适应物种：
Human, Mouse
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 保存条件：
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 形态：
形式：Liquid 储存溶液：Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- 亚型：
IgG
- 免疫原：
Recombinant fusion protein containing a sequence corresponding to amino acids 614-843 of human RBM25 (NP_067062.1).
- 规格：
50 µl/100 µl/200 µl
| 规格： | 50 µl | 产品价格： | ￥1425.0 |
|---|---|---|---|
| 规格： | 100 µl | 产品价格： | ￥2370.0 |
| 规格： | 200 µl | 产品价格： | ￥3930.0 |
分子量：Calculated MW: 17kDa/32kDa/33kDa/100kDa
Observed MW: 120kDa
细胞定位：Cytoplasm, Nucleus speckle
稀释方法：WB 1:200 - 1:2000
IF 1:50 - 1:200
总结：RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
Observed MW: 120kDa
细胞定位：Cytoplasm, Nucleus speckle
稀释方法：WB 1:200 - 1:2000
IF 1:50 - 1:200
总结：RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.
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RBM25 Rabbit pAb (APR22062N)
￥1425 - 3930
